Protein structure, dynamics and modelling (BMB834, 5 ECTS)

View on the SDU building

The aim of the course is to enable the student to understand protein structure and related computational techniques to investigate protein structure. This is important in regard to protein function in biological systems, understanding protein interactions, design of protein-targeting drugs and protein-based drugs, and optimization of enzyme activities.

The course builds on the knowledge acquired in: Molecular Biology and Protein Chemistry (BMB832, Conversion class) (or similar) “Fundamentals of bioinformatics” (DM847), Introduction to programming (DM857) (or similar).

The course provides an academic basis for conducting computational protein structure analysis, and for studying protein structure-function relationships using computational tools, including macromolecular modelling methods that are part of the degree.

After completing the course, the student is expected to be able to:

  • Acquire knowledge within the field of structural biology, protein structure and simulation
  • Understand and apply common terms and parameters in the context of protein structure analysis
  • Interpretation of experimental data using computational methods within the field of protein structure and dynamics
  • Understand principles of bioanalytical methods for measurements of protein structure and for determining structural constraints, including X-ray diffraction, NMR spectroscopy, mass spectrometry, calorimetry, scattering, cryoelectron microscopy
  • Understand basic principles and applications of High-performance computing for protein structure modelling and simulation
  • Perform simple protein structure modelling/simulation experiments using computational tools and be familiar with the underlying theory

More information about the course is available here.

University of Southern Denmark, Department of Biochemistry and Molecular Biology
Ole Nørregaard Jensen, Peter Husen