Peter Husen

Peter Husen
Assistant Professor

Department of Physics, Chemistry and Pharmacy
University of Southern Denmark
Campusvej 55, 5230 Odense M
Denmark


Room: V12-603b-2
Tel: +45-6550-2532
E-mail: phusen@sdu.dk

Curriculum Vitae

Research: I work on multiscale studies of molecular processes in metabolic enzymes, including the cytochrome bc1 protein complex, which is responsible for transport of electric charge across a cellular membrane as part of both the photosynthetic and respiratory pathways, and the ETF enzyme involved in fatty acid metabolisms. These enzymes serve vital energy transduction functions in the cell, but are also possible sources of harmful reactive oxgen species (ROS), such as superoxide. I apply a combination of molecular dynamics simulations with quantum chemical calculations to model electron and proton transfer processes within the complex, which could lead to superoxide production, and to model binding of ligand molecules, such as drugs, which could interfere with the function of the enzymes.

Development: I also take part in development of the scandinaVIan KIt for nanoscale modelinG (VIKING), which is a software toolkit tailored for addressing biomedical research problems using multiscale computational modeling techniques.

Publications

Inhibition Mechanism of Antimalarial Drugs Targeting the Cytochrome bc1 Complex, Luise Jacobsen, Peter Husen, Ilia A. Solov'yov, Journal of Chemical Information and Modeling, 61, 1334−1345, (2021)
Correction to "Spontaneous Binding of Molecular Oxygen at the Qo-Site of the bc1 Complex Could Stimulate Superoxide Formation", Peter Husen, Ilia A. Solov'yov, Journal of the American Chemical Society, 142, 11314-11314, (2020)
Introducing VIKING: A Novel Online Platform for Multiscale Modeling, Vasili Korol, Peter Husen, Emil Sjulstok, Claus Nielsen, Ida Friis, Anders Frederiksen, Adrian Bøgh Salo, Ilia A. Solov'yov, ACS Omega, 5, 1254-1260, (2020)
Molecular Oxygen Binding in the Mitochondrial Electron Transfer Flavoprotein, Peter Husen, Claus Nielsen, Carlos F. Martino, Ilia A. Solov'yov, Journal of Chemical Information and Modeling, 59, 4868-4879, (2019)
Charge transfer at the Qo-site of the cytochrome bc1 complex leads to superoxide production, Adrian Bøgh Salo, Peter Husen, Ilia A. Solov'yov, Journal of Physical Chemistry B, 121, 1771-1782, (2017)