Free electron production in ion beam cancer therapy

Ion beam cancer therapy

A century ago, radiation therapy emerged as a significant tool in oncology. Proton beam experiments for cancer treatment commenced in the late 1950s. Still, it wasn't until 1990 that this approach was integrated into clinical practice. Over time, researchers recognized the potential of heavier particles, such as carbon nuclei, in delivering more effective treatment. This realization led to developing Ion Beam Cancer Therapy (IBCT), a sophisticated modality demonstrating increasing efficacy in treating specific cancer types.

At a microscopic scale, envision minuscule carbon particles within the beam engaging with molecules within cancer cells. These interactions precipitate the generation of secondary electrons, which serve as agents responsible for inducing damage to the cancerous cells. Remarkably, this intricate process unfolds within a few hundred attoseconds, highlighting its swift nature. Notably, collisions between carbon ions and water molecules play a pivotal role in this intricate dance of interactions.

Our focus is exploring the collisions between carbon ions and DNA in cancer cells. This pursuit offers an opportunity to delve into the quantum mechanical dynamics governing these events with precision. We aim to unravel the complexities underlying Ion Beam Cancer Therapy at a fundamental level. By wearing these intricacies, we strive to enhance our comprehension of this cutting-edge therapy, potentially paving the way for advancements in cancer treatment methodologies.

Recent Publications

Condensed Matter Systems Exposed to Radiation: Multiscale Theory, Simulations, and Experiment, Andrey V. Solov'yov, Alexey V. Verkhovtsev, Nigel J. Mason, Richard A. Amos, Ilko Bald, Gérard Baldacchino, Brendan Dromey,Martin Falk, Juraj Fedor, Luca Gerhards, Michael Hausmann, Georg Hildenbrand, Miloš Hrabovsk\'y, Stanislav Kadlec, Jaroslav Kočišek, Franck Lépine, Siyi Ming, Andrew Nisbet, Kate Ricketts, Leo Sala, Thomas Schlathölter, Andrew E. H. Wheatley, Ilia A. Solov'yov, Chemical Reviews, 124, 8014-8129, (2024)
Quantum mechanical simulations of a carbon ion colliding with a biological target, Andreas Alberg-Fløjborg, Adrian Bøgh Salo, Ilia A. Solov'yov, Journal of Physics B: Atomic, Molecular and Optical Physics, 53, 145202, (2020)
Kvantemekanisk simulering af elektrondynamikken i ionstrålekræftterapi, Adrian Bøgh Salo, Andreas Alberg-Fløjborg, Ilia A. Solov'yov, Kvant, 3, 18-20, (2018)
Free-electron production from nucleotides upon collision with charged carbon ions, Adrian Bøgh Salo, Andreas Alberg-Fløjborg, Ilia A. Solov'yov, Physical Review A, 98, 012702, (2018)
Free Electron Dynamics in Biological Tissue, Andreas Alberg Foldrup, Adrian Bøgh Salo, Odense, Denmark, Bachelor Thesis, University of Southern Denmark, (2017)